NF157

产品描述

NF157 significantly decreases the expression of metalloproteinase (MMP)-3, MMP-13, which can be used in the treatment of osteoarthritis (OA). NF157 is a highly selective nanomolar P2Y11 antagonist (pKi: 7.35). The IC50s are 463 nM, 1811 μM, 170 μM for P2Y11 (Ki=44.3 nM), P2Y1 (Ki=187 μM), P2Y2 (Ki=28.9 μM), respectively.

PRODUCT INFORMATION

Chemical Name: NF157

Cat. Number: LM8666MIN

CAS Number: 104869-26-3 

Chemical Structure:

体外活性

NF157 (30 and 60 μM; 24 hours) induces a significant reduction in the degradation of type II collagen in a dose-dependent manner. NF157 (30 and 60 μM; 24 hours) almost fully restores nuclear translocation of p65 triggered by TNF-α (10 ng/mL) and significantly reduces the luciferase activity of NF-κB. NF157 (60 μM) nearly fully rescues type II collagen from degradation induced by TNF-α (10 ng/mL). NF157 shows selectivity for P2Y11 over P2Y1 (>650-fold), P2Y2 (>650-fold), P2X2 (3-fold), P2X3 (8-fold), P2X4 (>22-fold), and P2X7 (>67-fold) but no selectivity over P2X1[1][2].

分子式

C49H34F2N6Na6O23S6

分子量

1443.13

别名

NF157

储存和溶解度

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

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