血清类粘蛋白1样蛋白1+2+3封闭多肽
别 名:ORMDL1 + ORMDL2 + ORMDL3 Antibody Blocking Peptide
Catalog Number:
LM87116DT
General Information
Species:
human
QC Testing
Activity:
Not tested
Purification:
HPLC
Usage Guide
Storage:
Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background:
The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3; all of which are human homologs of the S. cerevisiae ORM1 protein. Localized to the membrane of the endoplasmic reticulum, ORMDLs are multi-pass membrane proteins that are implicated in ?secretase (BACE) function, as well as expression of Presenilin (PSI), a protein involved in Alzheimer抯 disease (AD). ORMDL1 (ORM1-like protein 1), also known as Adoplin-1, is a widely expressed 153 amino acid member of the ORMDL family. Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDL2 (ORM1-like protein 2), also known as Adoplin-2, and ORMDL3 (ORM1-like protein 3) are expressed in tissues such as heart, brain, lung, liver and kidney. ORMDL3 exists as two isoforms due to alternative splicing events and may be a determinant of susceptibility to childhood asthma
Figures
VALIDATION IMAGES
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
本产品只适用于科研,不能用于临床诊断。严禁用于临床医疗及其他非科研用途!以实际收货产品说明书为准,网站说明书仅供参考。