YM-46303

产品描述

YM-46303 is an antagonist of mAChR

体内活性

Compared with oxybutynin, YM-46303 showed about 10 times higher inhibitory activity on bladder pressure during reflex rhythmic contractions, and increased selectivity of bladder contraction about saliva secretion in rats by about 5 times. Further evaluation of antimuscarinic effects on bradycardia and pressor in pithed rats, and on tremor in mice, show that YM-46303 can be useful for the treatment of urinary urge incontinence as a bladder-selective M3 antagonist with potent activities and fewer side effects. YM-46303 shows in vivo selective inhibitory activities on bladder pressure in reflexly-evoked rhythmic contraction against oxotremorine-induced salivary secretion. In addition, YM-46303 has potent activity in a guinea pig model of methacholine-induced bronchospasm on intravenous administration.

Cas No.

171722-81-9

分子式

C20H23ClN2O2

分子量

358.86

别名

YM-46303

储存和溶解度

( < 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years

本产品只适用于科研，不能用于临床诊断。严禁用于临床医疗及其他非科研用途！

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